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Title: In Silico Medicinal Chemist Location: Flexible with travel to San Francisco, CA, Vancouver Canada, Durham, NC, and other locations. Position: Full-time. Reports to the Director of Discovery Company: Nalu Bio is a biotech company creating chemistry-based cannabinoids for the consumer and pharmaceutical markets. Nalu Bio has developed a proprietary cannabinoid chemical synthesis platform that will set a new industry standard for pure, consistent, and quality cannabinoids. Our innovative chemistry will solve many of the quality and consistency issues that plague cannabis-derived products currently. We believe in the therapeutic potential of phytocannabinoids and believe through thoughtful chemistry we can design better molecules that are more druggable and efficacious. We have a world-class team highly experienced in healthcare, chemistry, cannabinoids, consumer packaged goods, and drug development. The Role: We are seeking an energetic, creative, skilled chemoinformatics and modeling organic/medicinal chemist to manage our early drug development in silico and medicinal chemistry aspects to design and refine scaffolds resulting in lead molecules. The ideal candidate will have practical experience with design of new molecules, in silico docking, QSAR and physicochemical characterization of cannabinoid based molecules. As the program evolves this position will be integral in honing in on functional groups, pharmacophores and/or motifs that elicit specific effects we can exploit to generate better designs (QSAR). The key responsibilities of this position are to design, screen, refine and justify designs for potential synthesis and subsequent in vitro and in vivo characterization of lead compounds. The Ideal Candidate: Ph.D. degree in chemistry or related field with 2-3 years experience, or MS degree with 5-7 years experience. 2+ years experience generating novel chemical entities/designs and using in silico software to predict their physical attributes (academic laboratory work is acceptable). R&D experience with cannabinoid chemistry and pharmacology is preferred. SAR/QSAR experience is preferred. Previous experience preparing manuscripts and grants is preferred. Chemical product characterization experience utilizing in silico assays/models is a must; e.g., ortho and allosteric docking, physicochemical characterization. Ensures project timelines and milestones are met while working seamlessly with our extended team at CRO’s, CMO’s, and development partners. Strong problem-solving skills and conversant with the current relevant literature. Proven ability to work in a team environment with colleagues from diverse backgrounds. Excellent communication skills and ability to present the rationale, key data, issues and accomplishments of the in silico and early drug development program to internal stakeholders, external collaborators and in scientific forums (e.g., conferences, peer reviewed publications). Contemporary expertise in early drug development and cannabinoid motifs preferred. Start-up experience is a plus! Why It’s Great to Work Here We work at Nalu Bio because we want to elevate the quality, consistency, and reliability of cannabinoids on the market through chemistry. We are driven by the therapeutic potential of cannabinoids and we believe consumers and companies deserve safer, more reliable products that improve everyday life. In addition to our deep sense of purpose, we love working here because: We are an innovative, collaborative, young company: we believe in partnerships, collaboration, and honesty so that we act fast, efficiently, and smart. Flexibility of hours: While we do have core hours for teamwork, we have kids, we work across time zones, and savor our morning workouts. Flexibility of location: While we do have an office and value face-to-face interaction, we know that a distributed workforce can be effective and leverage the best talent across the country. Employee Equity Plan: We want our employees to be invested in the company, and can participate in our employee equity plan. This role is currently not accepting new applicants.

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